MovDisordV3, Main, Exploration, bibRecord, 002510

Mortality in Parkinson's Disease : A 20-Year Follow-Up Study

Identifieur interne : 002510 ( Main/Exploration ); précédent : 002509; suivant : 002511

Mortality in Parkinson's Disease : A 20-Year Follow-Up Study

Auteurs : Anja Diem-Zangerl [Autriche] ; Klaus Seppi [Autriche] ; Gregor K. Wenning [Autriche] ; Eugen Trinka [Autriche] ; Gerhard Ransmayr [Autriche] ; Wilhelm Oberaigner [Autriche] ; Werner Poewe [Autriche]

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0223198

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Mortalité, Etude longitudinale, Survie.
Wicri :
- topic : Mortalité.

English descriptors

KwdEn :
- Follow up study, Mortality, Nervous system diseases, Parkinson disease, Survival.

Abstract

We determined mortality rates and predictors of survival in 238 consecutive patients with Parkinson's disease (PD) with symptom onset between 1974 and 1984. All patients were regularly followed at the Movement Disorder Clinic (Department of Neurology at the Innsbruck Medical University) until December 31, 2004, or death. As of December 31, 2004, 189 patients had died. Standardized mortality ratios (SMRs) increased over time. SMRs were 0.6 (95% CI 0.4-1.0) by 5 years, 0.9 (95% CI 0.7-1.2) by 10 years, 1.2 (95% CI 1.0-1.4) by 15 years, and 1.3 (95% CI 1.1-1.5) by 20 to 30 years. SMR for male patients was significantly increased to 1.3 (95% CI 1.1-1.6), whereas SMR increase of 1.2 (0.9-1.4) observed in female patients was not significant. Significantly increased SMRs were detected in patients with younger and older age of onset. Male gender, gait disorder, lack of tremor, and lack of asymmetry as presenting clinical features predicted poor survival in a Cox's proportional hazard analysis. This study demonstrates similar survival of patients with PD to the normal control population up to a disease duration of 10 years, followed by a modest rise of mortality with disease duration beyond 10 years compared with the general population. Under regular specialist care using all currently available therapies life expectancy in PD does not appear seriously compromised, but male gender, gait disorder, and absent rest tremor at presentation are associated with poorer long-term survival.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000E94
to stream PascalFrancis, to step Curation: 001E25
to stream PascalFrancis, to step Checkpoint: 000E06
to stream Main, to step Merge: 002F03
to stream Main, to step Curation: 002510

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Mortality in Parkinson's Disease : A 20-Year Follow-Up Study</title>
<author><name sortKey="Diem Zangerl, Anja" sort="Diem Zangerl, Anja" uniqKey="Diem Zangerl A" first="Anja" last="Diem-Zangerl">Anja Diem-Zangerl</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Department of Neurology, Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Department of Neurology, Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Department of Neurology, Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Trinka, Eugen" sort="Trinka, Eugen" uniqKey="Trinka E" first="Eugen" last="Trinka">Eugen Trinka</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Department of Neurology, Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ransmayr, Gerhard" sort="Ransmayr, Gerhard" uniqKey="Ransmayr G" first="Gerhard" last="Ransmayr">Gerhard Ransmayr</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology and Psychiatry, General Hospital of the City of Linz</s1>
<s3>AUT</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Department of Neurology and Psychiatry, General Hospital of the City of Linz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oberaigner, Wilhelm" sort="Oberaigner, Wilhelm" uniqKey="Oberaigner W" first="Wilhelm" last="Oberaigner">Wilhelm Oberaigner</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Clinical Epidemiology, Tyrolean State Hospital Ltd</s1>
<s2>Innsbruck</s2>
<s3>AUT</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Innsbruck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Department of Neurology, Innsbruck Medical University</wicri:noRegion>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">09-0223198</idno>
<date when="2009">2009</date>
<idno type="stanalyst">PASCAL 09-0223198 INIST</idno>
<idno type="RBID">Pascal:09-0223198</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000E94</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001E25</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000E06</idno>
<idno type="wicri:doubleKey">0885-3185:2009:Diem Zangerl A:mortality:in:parkinson</idno>
<idno type="wicri:Area/Main/Merge">002F03</idno>
<idno type="wicri:Area/Main/Curation">002510</idno>
<idno type="wicri:Area/Main/Exploration">002510</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Mortality in Parkinson's Disease : A 20-Year Follow-Up Study</title>
<author><name sortKey="Diem Zangerl, Anja" sort="Diem Zangerl, Anja" uniqKey="Diem Zangerl A" first="Anja" last="Diem-Zangerl">Anja Diem-Zangerl</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Department of Neurology, Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Department of Neurology, Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Department of Neurology, Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Trinka, Eugen" sort="Trinka, Eugen" uniqKey="Trinka E" first="Eugen" last="Trinka">Eugen Trinka</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Department of Neurology, Innsbruck Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ransmayr, Gerhard" sort="Ransmayr, Gerhard" uniqKey="Ransmayr G" first="Gerhard" last="Ransmayr">Gerhard Ransmayr</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology and Psychiatry, General Hospital of the City of Linz</s1>
<s3>AUT</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Department of Neurology and Psychiatry, General Hospital of the City of Linz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oberaigner, Wilhelm" sort="Oberaigner, Wilhelm" uniqKey="Oberaigner W" first="Wilhelm" last="Oberaigner">Wilhelm Oberaigner</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Clinical Epidemiology, Tyrolean State Hospital Ltd</s1>
<s2>Innsbruck</s2>
<s3>AUT</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Innsbruck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Innsbruck Medical University</s1>
<s3>AUT</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Department of Neurology, Innsbruck Medical University</wicri:noRegion>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Follow up study</term>
<term>Mortality</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Survival</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Mortalité</term>
<term>Etude longitudinale</term>
<term>Survie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Mortalité</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We determined mortality rates and predictors of survival in 238 consecutive patients with Parkinson's disease (PD) with symptom onset between 1974 and 1984. All patients were regularly followed at the Movement Disorder Clinic (Department of Neurology at the Innsbruck Medical University) until December 31, 2004, or death. As of December 31, 2004, 189 patients had died. Standardized mortality ratios (SMRs) increased over time. SMRs were 0.6 (95% CI 0.4-1.0) by 5 years, 0.9 (95% CI 0.7-1.2) by 10 years, 1.2 (95% CI 1.0-1.4) by 15 years, and 1.3 (95% CI 1.1-1.5) by 20 to 30 years. SMR for male patients was significantly increased to 1.3 (95% CI 1.1-1.6), whereas SMR increase of 1.2 (0.9-1.4) observed in female patients was not significant. Significantly increased SMRs were detected in patients with younger and older age of onset. Male gender, gait disorder, lack of tremor, and lack of asymmetry as presenting clinical features predicted poor survival in a Cox's proportional hazard analysis. This study demonstrates similar survival of patients with PD to the normal control population up to a disease duration of 10 years, followed by a modest rise of mortality with disease duration beyond 10 years compared with the general population. Under regular specialist care using all currently available therapies life expectancy in PD does not appear seriously compromised, but male gender, gait disorder, and absent rest tremor at presentation are associated with poorer long-term survival.</div>
</front>
</TEI>
<affiliations><list><country><li>Autriche</li>
</country>
<region><li>Tyrol (Land)</li>
</region>
<settlement><li>Innsbruck</li>
</settlement>
<orgName><li>Université de médecine d'Innsbruck</li>
</orgName>
</list>
<tree><country name="Autriche"><noRegion><name sortKey="Diem Zangerl, Anja" sort="Diem Zangerl, Anja" uniqKey="Diem Zangerl A" first="Anja" last="Diem-Zangerl">Anja Diem-Zangerl</name>
</noRegion>
<name sortKey="Oberaigner, Wilhelm" sort="Oberaigner, Wilhelm" uniqKey="Oberaigner W" first="Wilhelm" last="Oberaigner">Wilhelm Oberaigner</name>
<name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<name sortKey="Ransmayr, Gerhard" sort="Ransmayr, Gerhard" uniqKey="Ransmayr G" first="Gerhard" last="Ransmayr">Gerhard Ransmayr</name>
<name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name>
<name sortKey="Trinka, Eugen" sort="Trinka, Eugen" uniqKey="Trinka E" first="Eugen" last="Trinka">Eugen Trinka</name>
<name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002510 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002510 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:09-0223198
   |texte=   Mortality in Parkinson's Disease : A 20-Year Follow-Up Study
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Mortality in Parkinson's Disease : A 20-Year Follow-Up Study

Mortality in Parkinson's Disease : A 20-Year Follow-Up Study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri